As far as the guitar part this song is exactly two chords, and it's freakin awesome.

I went into a pretty detailed description of the tuning in my 
Bwomp tap. Slightly less than a quarter step down from C. But it doesn't 
really matter what tuning you play this in as long as the chords you're 
hitting are E and D (a quarter step down of course!)

First and last riff
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|----------------------------------|
|----------------------------------|
|----------------------------------|
|-6-6-----6-6-----6-6-----6--------|
|-4-4-----4-4-----4-4-----4--------|

Then it reverses...
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|----------------------------------|
|-----6-6-----6-6-----6-6-----6-6--|
|-----4-4-----4-4-----4-4-----4-4--|


Chorus
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|----------------------------------|
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|----------------------------------|
|-4---------------4----------------|
|-2---------------2----------------|


Verse (Look familier?)
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|----------------------------------|
|----------------------------------|
|----------------------------------|
|-6-6-----6-6-----6-6-----6--------|
|-4-4-----4-4-----4-4-----4--------|