Standard tuning, Powerchord it all if you want. That's probably how Spoon plays it.

INTRO: C5 G5 C5 F5 A... E5 F5
C5 G5 C5 F5 A5 (let ring)

VERSE:
       A5                            E5  F5
She was smoking up all his cigarettes
C5      G5       C5             E5   F5
  And putting 'em out in his hand
A5                               E5     F5
  She said that you think this hurts now, kid, well
C5      G5       C5     E5  F5
  Just wait till later man
A5
This is fucking torture to me, it's fucking torture


CHORUS:
C5     G5    C5      F5      E5
Nefarious, nefarious
A5                             E5  F5
  It's enough to have to meet ya

Nefarious, nefarious
And there's nothing that could reach ya

And that's pretty much the rest of the song. Only, occasionally from the A chord it goes 
to A# instead of F.

Rest of the lyrics:

What's good, what's not so good
Sometimes it's hard for her to tell
What's good, what's not so good,
Sometimes it's hard
When she knows you so well and when she knows you so well
And now your teeth are red and there's a little bit about you I don't
wanna know, uh huh
And now your teeth are all red and there's a little bit about you I
don't wanna know, uh huh
But when there's something that wants this much to happen,
There's no need to be alarmed.
But I'm not so sure if I want to get in that car,
Because I caught you cheating, and caulking your chair
And now your teeth are all red and there's a little bit about you I
don't wanna know, uh huh
And now your teeth are all red and there's a little bit about you I
don't wanna know, uh huh
Nefarious, nefarious
It's enough to have to meet ya
Nefarious, nefarious
And there's nothing that could reach ya
And you're tearing me apart, tearing me apart,
It's enough to have to meet ya.